News

 

Study of Immune Protein Could Help Fight Tuberculosis, Other Pathogens

Scientists at UT Austin have revealed how a protein called ISG15 helps the human immune system fight certain pathogens, including the microbe that causes tuberculosis. In 2012, the group was part of a study that demonstrated that ISG15 stimulates the release of a cytokine, Interferon-g, important in the response to pathogenic bacteria. With this latest work, published this week in the journal Molecular Cell, these scientists have identified the cell surface receptor for ISG15 and determined the initial steps in how it activates the secretion of a range of cytokines.

Jon Huibregtse, UT Austin professor of molecular biosciences who led the study, said this may provide new insights into how to modulate immune responses and treat microbial infections.

“We think we may be on the trail of an entirely new mechanism for stimulating cytokine secretion,” said Huibregtse, “and that this might have implications for a wide variety of infectious diseases.”

Read the paper: Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor

Fall 2017 Letter from the Chair

What better example is there of how “What Starts Here Changes the World” than the legacy of our UT Austin alumni? This fall, the College of Natural Sciences inducted into its Hall of Honor alumna Gail Dianne Lewis, who has done life-saving research with Genentech to produce effective new treatments for patients with the aggressive HER2-positive form of breast cancer. Another alum, celebrated immunotherapy pioneer Dr. James Allison, made TIME magazine’s list of the world’s most influential people and was inducted into the American Academy of Arts & Sciences this year. Capping it all, the 2017 Nobel Prize for Physiology or Medicine was recently shared by our alum Michael Young for discovering the molecular circuits underlying circadian rhythms.

A revolution in human health is coming about not only because of our alumni, but through ongoing efforts at The University of Texas at Austin. The groundbreaking work our researchers are doing, increasingly in coordination with faculty in the Dell Medical School, is ushering in a new era of biomedical research and education on campus. You’ll find evidence of it with our outstanding new faculty members, our exciting new cryo-electron microscopy facility, and our remarkable graduate students and undergraduates. Your support for the outstanding research and amazing people in our Texas Molecular Biosciences community ensures that the “What Starts Here…” legacy continues for generations to come. More news from the Department is here and on the College website. Please consider a gift to help support our work.

Daniel Leahy
Chair, Department of Molecular Biosciences

 

New MBS Faculty Member Receives Etter Early Career Award

mclellanJason McLellan, future associate professor in the Department of Molecular Biosciences, has received the Etter Early Career Award from the American Crystallographic Association.

The Etter Early Career award, which was established in 2002, seeks to recognize outstanding achievement and exceptional potential in crystallographic research demonstrated by a scientist at an early stage of their independent career.

McLellan’s research focuses on applying structural information to the rational design of interventions for viruses, specifically the respiratory syncytial virus (RSV). According to the Centers for Disease Control and Prevention, nearly every child in the US catches RSV, a virus that infects the lungs and respiratory tract, by the age of two.

He has been working to develop a monoclonal antibody, a type of antibody that targets only one specific protein, which could act as a vaccine surrogate to prevent severe RSV in infants.

McLellan, who is currently an assistant professor at Dartmouth College, will join the UT Austin faculty in January 2018.

Jonghwan Kim Receives Grant to Study Preterm Births

The Burroughs Wellcome Fund has awarded Jonghwan Kim, an assistant professor in the Department of Molecular Biosciences at The University of Texas at Austin, a four-year, $600,000 grant to study the biological complexities of preterm birth.

Surprisingly, little is known about the biological mechanisms that occur during birth.  Even less is known about what causes preterm birth.  Defined as babies born before 37 weeks, preterm birth occurs in nearly 13 percent of all U.S births, with African-Americans and Hispanics having an even higher rate.

Preterm Birth is a major public health problem. Many preterm births lead to long-term health problems and developmental difficulties. There are also the sociological issues of families going bankrupt and marriages dissolving.

Kim’s research project is titled “Identifying genetic factors controlling normal and abnormal placental development.”

Burroughs Wellcome Fund’s ultimate goal is to help develop preventive strategies by enabling interdisciplinary teams to collaborate in learning more about preterm birth.

Fall 2016 Letter from the Chair

Dear Friends of UT Molecular Biosciences,​

This fall, UT Austin welcomed its largest incoming class to date, and we are excited to have many of these new Longhorns in the Department of Molecular Biosciences. We welcomed a new faculty member who has done groundbreaking research in CRISPR gene-editing and are preparing a new research facility that allows scientists to see the inner workings of cells at higher resolution than ever before. We also are celebrating Professor John Wallingford's election as president of the Society for Developmental Biology and the achievements of our alumnus, Dr. Jim Allison, who The New York Times featured prominently for his leadership in immunotherapy cancer treatment. We are thankful for your continued support. You're essential in making UT Austin a science education leader and a hub for discovery and innovation that changes the world.


Dan Leahy
Chair, Department of Molecular Biosciences

P.S. Giving from alumni, parents, and friends allows us to pursue strategic initiatives and to support our faculty and students in their education and research endeavors. Please consider making a gift to UT Molecular Biosciences today.

Wallingford Elected President Society for Developmental Biology

Professor John Wallingford of the Department of Molecular Biosciences has been elected president of the Society for Developmental Biology. The Society, a non-profit, has nearly 2,000 members and provides an international forum for research, education and career development in developmental biology.

Through his work, Wallingford seeks to integrate systems biology and bioinformatics with novel strategies for in vivo imaging. The ultimate aim of his research is understanding the cause of human developmental disorders.

Wallingford began his career in developmental biology as an undergraduate at Wesleyan University, and continued as a Ph.D. student at the University of Texas at Austin. His postdoctoral research occurred jointly at the University of California, Berkeley and Caltech, where he launched a research program seeking to understand how cellular form and function arise in developing embryos. Since returning to the University of Texas at Austin as a faculty member, his research has integrated systems biology and bioinformatics; its ultimate aim is to understand the causes of human developmental disorders.

Professor Wallingford has received numerous teaching awards, as well as an Early Career Scientist Award from the Howard Hughes Medical Institute, an Early Investigator Award from the American Asthma Foundation and a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund.

Steven Vokes Receives Grant for Cancer Research

090121 VokesThe St. Baldrick’s Foundation has awarded a $100,000 grant to Associate Professor Steven Vokes for his research to identify cures and better treatments for childhood cancers.

Medulloblastoma, the most common brain cancer in children, is formed by mutations that active a signaling pathway. With his grant from St. Baldrick’s, Dr. Vokes and his team are investigating how this pathway controls genes through specific DNA regions. By studying these regions, they hope to find a possible therapeutic target for medulloblastoma. 

"One of the challenges in today's highly competitive environment is that even great ideas take a long time to get funded. St. Baldrick's has a streamlined review process that quickly funds promising research. Their support has allowed us to quickly initiate experiments in a promising new area that we would otherwise be unable to pursue,” Vokes said.

St. Baldrick’s, a California-based nonprofit, is the largest private funder of childhood cancer research grants. The nonprofit recently awarded 79 grants totaling over $22 million. St. Baldrick's funds are granted to some of the top childhood cancer research experts working to find improved treatments and cures for childhood cancers. 

Discovery Sheds New Light on RNA Regulation

Scientists at the University of Texas at Austin have disproven a decades-old assumption about the molecular machinery responsible for producing proteins in all living things. The discovery could force researchers to rethink how they interpret results of experiments related to this machinery.

fruit fly700

Floating in every cell in your body are molecules of RNA, which act as templates for all the different flavors of protein that are essential for life. Often, an RNA molecule contains within itself elements that control if and when to make protein. Other elements can help guide the RNA to the right places inside the cell. The assumption, going right back to the earliest studies of gene regulation, was that control elements embedded in one RNA only affect what happens to that RNA.

Paul Macdonald, a professor of molecular biosciences, and his team discovered that a control element in one RNA can affect the production of proteins from other RNAs. Control elements can even affect production of proteins from completely different types of RNAs. They made the discovery by studying the developing embryos of fruit flies.

For researchers trying to understand what individual genes do and how they get translated into proteins, this poses a problem. A typical approach involves "knocking out" a gene, by genetically engineering mutations in it's associated RNA, to see what biological processes break down. Macdonald's finding suggests that removing one RNA could potentially affect the expression of other RNAs.

The findings were published online in the open access journal eLife on April 22.

NSF 2016 Graduate Research Fellowship Winners Announced

MBS would like to congratulate our graduate student winners and honorable mentions for the NSF 2016 Graduate Research Fellowship. It was a tough competition, with a total of 17,000 applicants and 2,000 fellowships (12% success rate). Applications were up from last year, when 16,500 applied for the same number of awards.

The MBS award recipients included Alexander Boulgakov (CMB) and Alexandra Helene Nishida (Microbiology). Honorable mentions include Caroline Davis (Biochemistry), Claire McWhite (Evolutionary Biology), Austin Cole (Evolutionary Biology), and Joshua Black (Microbial Biology).

A total of 28 UT-Austin students were awarded fellowships. This includes undergraduate seniors at UT who plan to enroll in grad school in Fall 2016, as well as first- and second-year grad students.

The breakdown by college at UT is as follows:

  • Natural Sciences: 10 fellowships (3 undergrad; 7 grad)
  • Engineering: 11 fellowships (5 undergrad; 6 grad)
  • Geosciences: 4 fellowships (1 undergrad; 3 grad)
  • Liberal Arts: 3 fellowships (1 undergrad; 2 grad)

For more information, checkout the NSF press release: http://www.nsf.gov/news/news_summ.jsp?cntn_id=138123&WT.mc_id=USNSF_51&WT.mc_ev=click

See the CNS annoucement here.

Spring 2016 Letter from the Chair

It’s an honor to introduce myself to you as the chair of the Department of Molecular Biosciences. Established in 2013, our department is the largest in the College. Our outstanding faculty members have already proven their strong commitment to making the department a world leader in research and education.

I received a bachelor’s degree in mathematics from Yale University, a Ph.D. in biophysics from Stanford University, and conducted postdoctoral research at Columbia University before joining the faculty at Johns Hopkins University School of Medicine. My research interests center around how specific hormones and growth factors trigger cells to grow or differentiate at just the right time and in just the right way to develop and maintain us in all of our complexity. To investigate this problem I use the tools of structural biology—X-ray crystallography and cryo-electron microscopy—to study the conformational changes in specific cell-surface receptors that occur when factors bind and how these changes alter cell growth and behavior. Many of the growth signals we study go awry in cancer, and we are very interested in learning what goes wrong in these cases and how that knowledge might contribute to the development of new cancer therapies. A new lab in the Larry R. Faulkner Nano Science and Technology Building that will be used by me and other faculty in the department is being equipped with state-of-the-art instruments to support this growing area of research.

Our faculty members span the gamut of biomedical and molecular bioscience research, ranging from those who work on regulation and organization of metabolic pathways, to the protein and nucleic acid structure, to infectious diseases. These faculty members are developing novel approaches to biological problems and offer unique perspectives to our students at both the undergraduate and graduate levels.

Central to this continual transformation are our close associations with a number of interdisciplinary institutes, centers, and facilities. These include the Institute for Cellular and Molecular Biology, the Center for Systems and Synthetic Biology, the John Ring LaMongagne Center for Infectious Disease, the Center for Computational Biology and Bioinformatics, and the Genome Sequencing and Analysis Facility. These intellectual and technological drivers further provide bridges between the faculty and broader clinical and commercial communities, enhance the productivity of the faculty, and enliven our educational and outreach efforts.

My goal as chair is to help advance biomedical sciences and prepare the College for strong, ongoing collaboration with the Dell Medical School. The opportunity to interact and coordinate with partners in the newly forming medical school is exciting for our department and UT Austin.

I am committed to doing all I can to ensure that molecular biosciences at UT Austin not only remains strong but advances its position as a world leader in research and education . As a stakeholder in our success, you help distinguish UT Molecular Biosciences from its peers, and we need your help financially. In this spring season, please consider making a gift to the department. Giving from alumni, parents, and friends allows us to pursue strategic initiatives and to support our faculty and students in their education and research endeavors.

Thank all of you for your support, which will make a tremendous difference in our day-to-day work.

Dan