Research Areas
Biochemistry
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Jeffrey E Barrick Associate Professor Lorene Morrow Kelley Professorship in Microbiology Microbial experimental evolution and synthetic biology |
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Karen S Browning Professor Mechanism And Regulation Of Eukaryotic Protein Synthesis. My research focuses on the initiation of protein synthesis in higher plants. |
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Andrew Ellington Professor Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology | Wilson M. and Kathryn Fraser Research Professorship in Biochemistry |
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Ilya J Finkelstein Associate Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Biophysical Studies of Molecular Machines |
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Marvin L Hackert Professor, Department of Molecular Biosciences William Shive Centennial Professorship in Biochemistry |
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David W Hoffman Associate Professor NMR Spectroscopy, Position-specific Isotope Analysis, Protein and RNA Structure |
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Andres Jara-Oseguera Assistant Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Molecular and cellular mechanisms of electrical signaling, biophysics of ion channel proteins. |
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Daniel J Leahy Department Chair, Molecular Biosciences, Professor Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology |
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Paul M Macdonald Professor, Professor Emeritus Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology How mRNAs become localized within cells, and how their translation is regulated |
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Edward M Marcotte Professor Mr. and Mrs. Corbin J. Robertson, Sr. Regents Chair in Molecular Biology #1 |
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Andreas Matouschek Associate Dean, Professor Mechanisms of protein machines, protein folding, unfolding, and degradation. |
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Jason McLellan Professor The Robert A. Welch Chair in Chemistry Structural Basis of Host–Pathogen Interactions |
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Ian J Molineux Professor Mechanisms of phage infection and genome ejection in vivo; phage evolutionary genetics and applications of phage |
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Tanya T Paull Professor, Professor of Oncology Burl G. and Lorene L. Rogers Chair in Human Health Regulation of DNA double-strand break repair and oxidative stress signaling |
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Shelley M Payne Professor, Professor of Medical Education Marie Betzner Morrow Centennial Chair | Distinguished Teaching Professor Advisor to the Dean for Diversity & Inclusion |
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Jon D Robertus Professor Emeritus Benjamin Clayton Centennial Professorship in Biochemistry Biochemistry: Structural Biology, Protein Engineering, And Drug Design |
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Gwendolyn M Stovall Assistant Professor of Practice Gwen Stovall leads the FRI Aptamer Stream, where students use biochemistry and molecular biology to develop tools made of RNA and DNA. |
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Caleb D Swaim I study the extracellular signaling activity of ISG15. We are interested in how ISG15 works with its receptor LFA-1 to stimulate cytokine re |
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David W Taylor Jr Assistant Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Directly visualizing molecular machines |
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Keiko Torii Professor Johnson & Johnson Centennial Chair in Plant Cell Biology Shaping Patterns in Plant Development |
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Zac Wentzell Graduate Research Assistant PhD student researching metabolic engineering in plants. Currently my work focuses on natural rubber and omega-3 fatty acid biosynthesis. |
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Yan Zhang Professor Structural And Biophysical Studies Of phosphatases in eukaryotic transcription, Structure-Based Drug Design. |
Biophysics
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Andrew Ellington Professor Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology | Wilson M. and Kathryn Fraser Research Professorship in Biochemistry |
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Ilya J Finkelstein Associate Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Biophysical Studies of Molecular Machines |
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Andres Jara-Oseguera Assistant Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Molecular and cellular mechanisms of electrical signaling, biophysics of ion channel proteins. |
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Daniel J Leahy Department Chair, Molecular Biosciences, Professor Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology |
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Edward M Marcotte Professor Mr. and Mrs. Corbin J. Robertson, Sr. Regents Chair in Molecular Biology #1 |
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Andreas Matouschek Associate Dean, Professor Mechanisms of protein machines, protein folding, unfolding, and degradation. |
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Jason McLellan Professor The Robert A. Welch Chair in Chemistry Structural Basis of Host–Pathogen Interactions |
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Ian J Molineux Professor Mechanisms of phage infection and genome ejection in vivo; phage evolutionary genetics and applications of phage |
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David W Taylor Jr Assistant Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Directly visualizing molecular machines |
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Yan Zhang Professor Structural And Biophysical Studies Of phosphatases in eukaryotic transcription, Structure-Based Drug Design. |
Birth Defects
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Seema Agarwala Associate Professor Cellular and molecular bases of Neural Tube Closure and birth defects |
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Jonghwan Kim Associate Professor Transcriptional and epigenetic regulations in Pluripotent stem cells and trophoblast lineage development |
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Steven A Vokes Associate Professor Understanding how transcriptional repressors, especially underlying Hedgehog signaling, interface with chromatin to regulate development |
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John B Wallingford Professor Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology We combine in vivo imaging with systems biology to explore the cell biological basis of embryonic development |
Cell Biology
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Seema Agarwala Associate Professor Cellular and molecular bases of Neural Tube Closure and birth defects |
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Lauren I Ehrlich Associate Professor, Associate Professor of Oncology Lorene Morrow Kelley Endowed Faculty Fellowship Fund Thymocyte: stromal cell interactions in T cell development and T-ALL |
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Janice A Fischer Professor, Director, Academic Center Molecular genetics of the ubiquitin pathway in Drosophila |
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Andres Jara-Oseguera Assistant Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Molecular and cellular mechanisms of electrical signaling, biophysics of ion channel proteins. |
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Jonghwan Kim Associate Professor Transcriptional and epigenetic regulations in Pluripotent stem cells and trophoblast lineage development |
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Paul M Macdonald Professor, Professor Emeritus Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology How mRNAs become localized within cells, and how their translation is regulated |
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Andreas Matouschek Associate Dean, Professor Mechanisms of protein machines, protein folding, unfolding, and degradation. |
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Kyle M Miller Associate Professor Lorene Morrow Kelley Professorship in Microbiology Molecular mechanisms of DNA damage responses and chromatin involved in cancer and its treatments |
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Tanya T Paull Professor, Professor of Oncology Burl G. and Lorene L. Rogers Chair in Human Health Regulation of DNA double-strand break repair and oxidative stress signaling |
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Caleb D Swaim I study the extracellular signaling activity of ISG15. We are interested in how ISG15 works with its receptor LFA-1 to stimulate cytokine re |
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Keiko Torii Professor Johnson & Johnson Centennial Chair in Plant Cell Biology Shaping Patterns in Plant Development |
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John B Wallingford Professor Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology We combine in vivo imaging with systems biology to explore the cell biological basis of embryonic development |
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Cancer
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Lauren I Ehrlich Associate Professor, Associate Professor of Oncology Lorene Morrow Kelley Endowed Faculty Fellowship Fund Thymocyte: stromal cell interactions in T cell development and T-ALL |
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Ilya J Finkelstein Associate Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Biophysical Studies of Molecular Machines |
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Gregory C Ippolito Research Associate Professor, Associate Professor of Oncology Normal and malignant B-cell immunology. Antibody repertoires. Vaccines and infectious diseases. |
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Jonghwan Kim Associate Professor Transcriptional and epigenetic regulations in Pluripotent stem cells and trophoblast lineage development |
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Edward M Marcotte Professor Mr. and Mrs. Corbin J. Robertson, Sr. Regents Chair in Molecular Biology #1 |
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Kyle M Miller Associate Professor Lorene Morrow Kelley Professorship in Microbiology Molecular mechanisms of DNA damage responses and chromatin involved in cancer and its treatments |
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Tanya T Paull Professor, Professor of Oncology Burl G. and Lorene L. Rogers Chair in Human Health Regulation of DNA double-strand break repair and oxidative stress signaling |
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Christopher S Sullivan Professor Our lab seeks to understand how viruses interact with the host non-coding RNA machineries to replicate, induce tumors, and cause pathogenesi |
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David W Taylor Jr Assistant Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Directly visualizing molecular machines |
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Haley Tucker Professor Emerita Our group works on transcriptional regulation of stem cells develpment and hematopoiesis |
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Steven A Vokes Associate Professor Understanding how transcriptional repressors, especially underlying Hedgehog signaling, interface with chromatin to regulate development |
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Developmental Biology
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Seema Agarwala Associate Professor Cellular and molecular bases of Neural Tube Closure and birth defects |
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Z. Jeffrey Chen Professor D. J. Sibley Centennial Professorship in Plant Molecular Genetics Genomic and Epigenetic Bases of Polyploidy and Hybrid Vigor |
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Janice A Fischer Professor, Director, Academic Center Molecular genetics of the ubiquitin pathway in Drosophila |
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Enamul Huq Professor Light signal transduction in plants witha a focus on mechanisms of light-regulated protein degradation and pre-mRNA splicing in Arabidopsis |
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Jonghwan Kim Associate Professor Transcriptional and epigenetic regulations in Pluripotent stem cells and trophoblast lineage development |
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Paul M Macdonald Professor, Professor Emeritus Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology How mRNAs become localized within cells, and how their translation is regulated |
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Keiko Torii Professor Johnson & Johnson Centennial Chair in Plant Cell Biology Shaping Patterns in Plant Development |
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Haley Tucker Professor Emerita Our group works on transcriptional regulation of stem cells develpment and hematopoiesis |
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Steven A Vokes Associate Professor Understanding how transcriptional repressors, especially underlying Hedgehog signaling, interface with chromatin to regulate development |
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John B Wallingford Professor Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology We combine in vivo imaging with systems biology to explore the cell biological basis of embryonic development |
Genes, Genetics & Genomics
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Jeffrey E Barrick Associate Professor Lorene Morrow Kelley Professorship in Microbiology Microbial experimental evolution and synthetic biology |
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Z. Jeffrey Chen Professor D. J. Sibley Centennial Professorship in Plant Molecular Genetics Genomic and Epigenetic Bases of Polyploidy and Hybrid Vigor |
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Andrew Ellington Professor Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology | Wilson M. and Kathryn Fraser Research Professorship in Biochemistry |
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Ilya J Finkelstein Associate Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Biophysical Studies of Molecular Machines |
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Janice A Fischer Professor, Director, Academic Center Molecular genetics of the ubiquitin pathway in Drosophila |
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Gregory C Ippolito Research Associate Professor, Associate Professor of Oncology Normal and malignant B-cell immunology. Antibody repertoires. Vaccines and infectious diseases. |
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Jonghwan Kim Associate Professor Transcriptional and epigenetic regulations in Pluripotent stem cells and trophoblast lineage development |
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Edward M Marcotte Professor Mr. and Mrs. Corbin J. Robertson, Sr. Regents Chair in Molecular Biology #1 |
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Kyle M Miller Associate Professor Lorene Morrow Kelley Professorship in Microbiology Molecular mechanisms of DNA damage responses and chromatin involved in cancer and its treatments |
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Ian J Molineux Professor Mechanisms of phage infection and genome ejection in vivo; phage evolutionary genetics and applications of phage |
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Shelley M Payne Professor, Professor of Medical Education Marie Betzner Morrow Centennial Chair | Distinguished Teaching Professor Advisor to the Dean for Diversity & Inclusion |
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Caleb D Swaim I study the extracellular signaling activity of ISG15. We are interested in how ISG15 works with its receptor LFA-1 to stimulate cytokine re |
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Keiko Torii Professor Johnson & Johnson Centennial Chair in Plant Cell Biology Shaping Patterns in Plant Development |
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Haley Tucker Professor Emerita Our group works on transcriptional regulation of stem cells develpment and hematopoiesis |
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Steven A Vokes Associate Professor Understanding how transcriptional repressors, especially underlying Hedgehog signaling, interface with chromatin to regulate development |
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John B Wallingford Professor Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology We combine in vivo imaging with systems biology to explore the cell biological basis of embryonic development |
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Zac Wentzell Graduate Research Assistant PhD student researching metabolic engineering in plants. Currently my work focuses on natural rubber and omega-3 fatty acid biosynthesis. |
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Immunology
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Lauren I Ehrlich Associate Professor, Associate Professor of Oncology Lorene Morrow Kelley Endowed Faculty Fellowship Fund Thymocyte: stromal cell interactions in T cell development and T-ALL |
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Gregory C Ippolito Research Associate Professor, Associate Professor of Oncology Normal and malignant B-cell immunology. Antibody repertoires. Vaccines and infectious diseases. |
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Jason McLellan Professor The Robert A. Welch Chair in Chemistry Structural Basis of Host–Pathogen Interactions |
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Caleb D Swaim I study the extracellular signaling activity of ISG15. We are interested in how ISG15 works with its receptor LFA-1 to stimulate cytokine re |
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Haley Tucker Professor Emerita Our group works on transcriptional regulation of stem cells develpment and hematopoiesis |
Infectious Disease
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Bryan W Davies Associate Professor We investigate protein-based antibiotics and bacteria-host interactions. |
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Andrew Ellington Professor Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology | Wilson M. and Kathryn Fraser Research Professorship in Biochemistry |
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Rasika M Harshey Professor Lorene Morrow Kelley Professorship in Microbiology DNA transposition, Replicative repair, flagella motility and signaling, bacterial surface colonization |
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Gregory C Ippolito Research Associate Professor, Associate Professor of Oncology Normal and malignant B-cell immunology. Antibody repertoires. Vaccines and infectious diseases. |
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Jason McLellan Professor The Robert A. Welch Chair in Chemistry Structural Basis of Host–Pathogen Interactions |
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Shelley M Payne Professor, Professor of Medical Education Marie Betzner Morrow Centennial Chair | Distinguished Teaching Professor Advisor to the Dean for Diversity & Inclusion |
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Christopher S Sullivan Professor Our lab seeks to understand how viruses interact with the host non-coding RNA machineries to replicate, induce tumors, and cause pathogenesi |
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Caleb D Swaim I study the extracellular signaling activity of ISG15. We are interested in how ISG15 works with its receptor LFA-1 to stimulate cytokine re |
Microbiology
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Jeffrey E Barrick Associate Professor Lorene Morrow Kelley Professorship in Microbiology Microbial experimental evolution and synthetic biology |
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Bryan W Davies Associate Professor We investigate protein-based antibiotics and bacteria-host interactions. |
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Lauren I Ehrlich Associate Professor, Associate Professor of Oncology Lorene Morrow Kelley Endowed Faculty Fellowship Fund Thymocyte: stromal cell interactions in T cell development and T-ALL |
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Ilya J Finkelstein Associate Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Biophysical Studies of Molecular Machines |
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Rasika M Harshey Professor Lorene Morrow Kelley Professorship in Microbiology DNA transposition, Replicative repair, flagella motility and signaling, bacterial surface colonization |
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Andreas Matouschek Associate Dean, Professor Mechanisms of protein machines, protein folding, unfolding, and degradation. |
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Jason McLellan Professor The Robert A. Welch Chair in Chemistry Structural Basis of Host–Pathogen Interactions |
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Ian J Molineux Professor Mechanisms of phage infection and genome ejection in vivo; phage evolutionary genetics and applications of phage |
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Shelley M Payne Professor, Professor of Medical Education Marie Betzner Morrow Centennial Chair | Distinguished Teaching Professor Advisor to the Dean for Diversity & Inclusion |
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Christopher S Sullivan Professor Our lab seeks to understand how viruses interact with the host non-coding RNA machineries to replicate, induce tumors, and cause pathogenesi |
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Caleb D Swaim I study the extracellular signaling activity of ISG15. We are interested in how ISG15 works with its receptor LFA-1 to stimulate cytokine re |
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Zac Wentzell Graduate Research Assistant PhD student researching metabolic engineering in plants. Currently my work focuses on natural rubber and omega-3 fatty acid biosynthesis. |
Molecular Biology
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Seema Agarwala Associate Professor Cellular and molecular bases of Neural Tube Closure and birth defects |
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Jeffrey E Barrick Associate Professor Lorene Morrow Kelley Professorship in Microbiology Microbial experimental evolution and synthetic biology |
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Karen S Browning Professor Mechanism And Regulation Of Eukaryotic Protein Synthesis. My research focuses on the initiation of protein synthesis in higher plants. |
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Z. Jeffrey Chen Professor D. J. Sibley Centennial Professorship in Plant Molecular Genetics Genomic and Epigenetic Bases of Polyploidy and Hybrid Vigor |
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Lauren I Ehrlich Associate Professor, Associate Professor of Oncology Lorene Morrow Kelley Endowed Faculty Fellowship Fund Thymocyte: stromal cell interactions in T cell development and T-ALL |
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Ilya J Finkelstein Associate Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Biophysical Studies of Molecular Machines |
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Janice A Fischer Professor, Director, Academic Center Molecular genetics of the ubiquitin pathway in Drosophila |
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Enamul Huq Professor Light signal transduction in plants witha a focus on mechanisms of light-regulated protein degradation and pre-mRNA splicing in Arabidopsis |
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Jonghwan Kim Associate Professor Transcriptional and epigenetic regulations in Pluripotent stem cells and trophoblast lineage development |
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Paul M Macdonald Professor, Professor Emeritus Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology How mRNAs become localized within cells, and how their translation is regulated |
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Edward M Marcotte Professor Mr. and Mrs. Corbin J. Robertson, Sr. Regents Chair in Molecular Biology #1 |
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Andreas Matouschek Associate Dean, Professor Mechanisms of protein machines, protein folding, unfolding, and degradation. |
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Jason McLellan Professor The Robert A. Welch Chair in Chemistry Structural Basis of Host–Pathogen Interactions |
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Kyle M Miller Associate Professor Lorene Morrow Kelley Professorship in Microbiology Molecular mechanisms of DNA damage responses and chromatin involved in cancer and its treatments |
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Ian J Molineux Professor Mechanisms of phage infection and genome ejection in vivo; phage evolutionary genetics and applications of phage |
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Tanya T Paull Professor, Professor of Oncology Burl G. and Lorene L. Rogers Chair in Human Health Regulation of DNA double-strand break repair and oxidative stress signaling |
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Shelley M Payne Professor, Professor of Medical Education Marie Betzner Morrow Centennial Chair | Distinguished Teaching Professor Advisor to the Dean for Diversity & Inclusion |
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Jon D Robertus Professor Emeritus Benjamin Clayton Centennial Professorship in Biochemistry Biochemistry: Structural Biology, Protein Engineering, And Drug Design |
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Gwendolyn M Stovall Assistant Professor of Practice Gwen Stovall leads the FRI Aptamer Stream, where students use biochemistry and molecular biology to develop tools made of RNA and DNA. |
|
|
Christopher S Sullivan Professor Our lab seeks to understand how viruses interact with the host non-coding RNA machineries to replicate, induce tumors, and cause pathogenesi |
|
|
|
|
|
|
|
Caleb D Swaim I study the extracellular signaling activity of ISG15. We are interested in how ISG15 works with its receptor LFA-1 to stimulate cytokine re |
|
|
|
|
Steven A Vokes Associate Professor Understanding how transcriptional repressors, especially underlying Hedgehog signaling, interface with chromatin to regulate development |
|
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John B Wallingford Professor Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology We combine in vivo imaging with systems biology to explore the cell biological basis of embryonic development |
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Zac Wentzell Graduate Research Assistant PhD student researching metabolic engineering in plants. Currently my work focuses on natural rubber and omega-3 fatty acid biosynthesis. |
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Yan Zhang Professor Structural And Biophysical Studies Of phosphatases in eukaryotic transcription, Structure-Based Drug Design. |
Plant Biology
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Karen S Browning Professor Mechanism And Regulation Of Eukaryotic Protein Synthesis. My research focuses on the initiation of protein synthesis in higher plants. |
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||
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|
Z. Jeffrey Chen Professor D. J. Sibley Centennial Professorship in Plant Molecular Genetics Genomic and Epigenetic Bases of Polyploidy and Hybrid Vigor |
|
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||
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Enamul Huq Professor Light signal transduction in plants witha a focus on mechanisms of light-regulated protein degradation and pre-mRNA splicing in Arabidopsis |
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Keiko Torii Professor Johnson & Johnson Centennial Chair in Plant Cell Biology Shaping Patterns in Plant Development |
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Zac Wentzell Graduate Research Assistant PhD student researching metabolic engineering in plants. Currently my work focuses on natural rubber and omega-3 fatty acid biosynthesis. |
Stem Cells & Regenerative Biology
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Seema Agarwala Associate Professor Cellular and molecular bases of Neural Tube Closure and birth defects |
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Lauren I Ehrlich Associate Professor, Associate Professor of Oncology Lorene Morrow Kelley Endowed Faculty Fellowship Fund Thymocyte: stromal cell interactions in T cell development and T-ALL |
|
|
|
Jonghwan Kim Associate Professor Transcriptional and epigenetic regulations in Pluripotent stem cells and trophoblast lineage development |
|
|
|
|
Haley Tucker Professor Emerita Our group works on transcriptional regulation of stem cells develpment and hematopoiesis |
|
|
|
Steven A Vokes Associate Professor Understanding how transcriptional repressors, especially underlying Hedgehog signaling, interface with chromatin to regulate development |
|
|
|
John B Wallingford Professor Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology We combine in vivo imaging with systems biology to explore the cell biological basis of embryonic development |
|
|
|
Yan Zhang Professor Structural And Biophysical Studies Of phosphatases in eukaryotic transcription, Structure-Based Drug Design. |
Systems & Synthetic Biology
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Jeffrey E Barrick Associate Professor Lorene Morrow Kelley Professorship in Microbiology Microbial experimental evolution and synthetic biology |
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Bryan W Davies Associate Professor We investigate protein-based antibiotics and bacteria-host interactions. |
|
|
|
|
Andrew Ellington Professor Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology | Wilson M. and Kathryn Fraser Research Professorship in Biochemistry |
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Ilya J Finkelstein Associate Professor Lorene Morrow Kelley Endowed Faculty Fellowship Fund Biophysical Studies of Molecular Machines |
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Jonghwan Kim Associate Professor Transcriptional and epigenetic regulations in Pluripotent stem cells and trophoblast lineage development |
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Edward M Marcotte Professor Mr. and Mrs. Corbin J. Robertson, Sr. Regents Chair in Molecular Biology #1 |
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|
Andreas Matouschek Associate Dean, Professor Mechanisms of protein machines, protein folding, unfolding, and degradation. |
|
|
Ian J Molineux Professor Mechanisms of phage infection and genome ejection in vivo; phage evolutionary genetics and applications of phage |
|
|
|
Christopher S Sullivan Professor Our lab seeks to understand how viruses interact with the host non-coding RNA machineries to replicate, induce tumors, and cause pathogenesi |
|
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Keiko Torii Professor Johnson & Johnson Centennial Chair in Plant Cell Biology Shaping Patterns in Plant Development |
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Steven A Vokes Associate Professor Understanding how transcriptional repressors, especially underlying Hedgehog signaling, interface with chromatin to regulate development |
|
|
|
John B Wallingford Professor Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology We combine in vivo imaging with systems biology to explore the cell biological basis of embryonic development |
|
|
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Zac Wentzell Graduate Research Assistant PhD student researching metabolic engineering in plants. Currently my work focuses on natural rubber and omega-3 fatty acid biosynthesis. |
Department of MBS, NHB 2.606, Stop A5000, 100 East 24th St., Austin, Texas 78712
General Inquiries: (512) 471-5105 FAX: (512) 471-1218
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