Bryan W. Davies

Bryan completed his B.Sc. in Biochemistry at McMaster University, Ph.D. in Molecular Biology at MIT and postdoctoral fellowship in infectious diseases at Harvard Medical School. He is an Associate Professor in the Departments of Molecular Biosciences and Medical Education. His research interests include antimicrobial discovery and development, bacteria-host interactions and microbe engineering.

The Davies Lab investigates protein-based antibiotics and bacteria-host interactions. Current projects include:

• Discovering synthetic peptide antibiotics: exploring the sequence-structure space of peptide antibiotics and how peptides with distinct antibacterial and in vivo properties are distributed across this landscape. 
• Developing antibacterial antibodies: developing single-chain antibodies that can target and/or directly kill specific bacteria. We are selecting and enhancing scaffolds to support these activities and investigating potential bacterial targets.
• Characterizing bacterial secretion systems and secreted proteins: exploring bacterial secretion systems and secreted proteins as sources of antibacterial scaffolds and routes to control bacterial growth and host interactions.
• Designing bacteria-host interactions: investigating and repurposing microbe-microbe and microbe-host interactions to develop bacteria that can influence human health.