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Partridge, Jon

Jonathan D Partridge

Research Associate, Assistant Professor of Instruction
Molecular Biosciences, Biology Instruction Office


j.partridge@utexas.edu

Phone: 512-232-2745

Office Location
PAI 1.13A

Postal Address
103 W 24TH ST
AUSTIN, TX 78712

 

1998-2001   BSc. (Hons) in Microbiology, The University of Sheffield, UK
2001-05   PhD. BBSRC student with Prof. Jeffrey Green, The University of Sheffield, UK
2005-06   Postdoctoral Researcher with Prof. Jeffrey Green, The University of Sheffield, UK
2007-09   Postdoctoral Researcher with Prof. Stephen Spiro, The University of Texas at Dallas, USA

2009-

 

Research Associate with Prof. Rasika Harshey, Dept. Molecular Biosciences, The University of Texas at Austin, USA

2018  

Lecturer, BIO Instruction Office, The University of Texas at Austin, USA

2018-  

Assistant Professor of Instruction, BIO Instruction Office, The University of Texas at Austin, USA

My current research focuses on better understanding mechanisms of bacterial motility, specifically how bacteria sense their environment, and remodel their motility accordingly. This response comes from control of the motor, which drives flagellar rotation. My main focus is in better understanding the role of two proteins important in the function of this motor. The first, FliL, is critical for swarming (a surfaced based mode of motility) and functions to maximize motor output while the second, YcgR, is mediated by the secondary messenger c-di-GMP and acts as a breaking mechanism to halt motility.

My previous research undertaken at The University of Texas at Dallas involved the study of the nitric-oxide sensitive transcriptional regulator NsrR. Prior to this I gained my PhD at The University of Sheffield (UK), where I further elucidated the regulon of the oxygen sensitive response-regulator FNR, and how the protein coordinated the adaption of E. coli to different growth conditions.

• Partridge, J.D., Nhu, N.T.Q., Dufour, Y.S., and Harshey, R.M. (2019). Escherichia coli remodels the chemotaxis pathway for swarming. mBio. March, 2019

• Partridge, J.D., Ariel, G., Schvartz, O., Harshey, R.M. and Be’er, A. (2018). 3D Architecture of a Bacterial Swarm. Sci. Rep. Oct. 2018

• Ariel, G., Rabani, A., Benisty, S., Partridge, J.D., Harshey, R.M. and Be’er, A. (2015). Swarming Bacteria Migrate by Lévy-Walk. Nature. Comm. Sept. 2015

• Harshey, R.M. and Partridge, J.D. (2015). Surviving in a Swarm. J. Mol. Biol. Aug. 2015

Partridge, J.D., Nieto, V. and Harshey, R.M. (2015). A new player at the flagellar motor: FliL controls both motor output and bias. M.Bio. Feb 24;6(2). Doi: 10.1128/mbio.02367-14

Partridge, J.D. and Harshey, R. (2013). More than motility: Salmonella flagella contribute to overriding surface friction and facilitate colony hydration during swarming. J. Bacteriol. 195:919-929 *Selected as a journal highlight by the American Society of Microbiology, Microbe Magazine, Feb. 2013

Partridge, J.D. and Harshey, R. (2013). Swarming: flexible roaming plans. J. Bacteriol. 195:909-918

• Lacey, M.M., Partridge, J.D. and Green, J. (2010). Escherichia coli K-12 YfgF is an anaerobic cyclic di-GMP phosphodiesterase with roles in cell surface re-modelling and the oxidative stress response. Microbiol. 156:2873-2886

Partridge, J. D., Bodenmiller, D. M., Humphrys, M. and Spiro, S. (2009). NsrR targets in the Escherichia coli genome: new insights into DNA sequence requirements for binding and a role for NsrR in the regulation of motility. Mol. Microbiol. 73:680-94

• Rankin, L. D., Bodenmiller, D. M., Partridge, J. D., Nishino, S. F., Spain, J. C. and Spiro, S. (2008). Escherichia coli NsrR regulates a pathway for the oxidation of 3-nitrotyramine to 4-hydroxy-3-nitrophenylacetate. J. Bacteriol. 190: 6170-6177

Partridge, J. D., Browning, D. F., Xu, M., Newnham, L. J., Scott, C., Poole, R. K. and Green, J. (2008). Characterization of the Escherichia coli K-12 ydhYVWXUT operon: regulation by FNR, NarL and NarP. Microbiology 154: 608-618

Partridge, J.D., Poole, R.K. and Green, J. (2007). The Escherichia coli yhjA gene, encoding a predicted cytochrome c peroxidise, is regulated by FNR and OxyR. Microbiology 153: 1499-1507

Partridge, J.D., Sanguinetti, G., Dibden, D,. Roberts, R.E., Poole, R.K. and Green, J. (2007). Transition of Escherichia coli from aerobic to micro-aerobic conditions involves fast and slow reacting regulatory pathways. J. Biol. Chem. 282: 11230-11237

Partridge, J. D., Scott, C., Tang, Y., Poole, R. K. and Green, J. (2006). Escherichia coli transcriptome dynamics during the transition from anaerobic to aerobic conditions. J. Biol. Chem. 281: 27806-27815 * Faculty of 1000 Recommended Article.

• Scott, C., Partridge, J. D., Stephenson, J. R, and Green J. (2003). DNA target sequence and FNR-dependent gene expression. FEBS Letters 541: 97-101.

 

2001-2005: Biotechnology and Biological Sciences Research Council Ph.D. scholarship award

2004: Awarded the Sir Hans Krebs award for Molecular Sciences – The University of Sheffield

2015: The Robert M. MacNab Award – Bacterial Locomotion and Signal Transduction meeting

 

 

PRESENTED TALKS

  • “Enhanced Motor Output is Critical for Swarming Success”. Conference on Collective Dynamics in Microorgansms and Cellular Systems, (Sede Boqer, Israel; May 2016)
  • “The FliL protein increases flagellar motor output in Salmonella” at BLAST XII (Bacterial Locomotion And Signal Transduction), (Tucson, USA; January 2013) *Selected as a Conference highlight. Mol. Microbiol. 91:6-25
  • “Regulation of coli motility by the nitric oxide transcriptional repressor NsrR” at BLAST X, (Cuernavaca, Mexico; January 2009) *Selected as a Conference highlight. Mol. Microbiol. 73:5-19
  • coli transcriptome dynamics during the transition from anaerobic to aerobic growth”. Invited talk (J. Green) and poster (J. Partridge) at the Gordon Research Conference on Microbial Stress Responses (Mount Holyoke College, MA, U.S.A; July, 2006)
  • “Characterization of coli yfgF: a cyclic-di-GMP phosphodiesterase?” At the 158th Meeting of the Society for General Microbiology (invited talk) (Warwick, UK; April, 2006)

POSTER PRESENTATIONS

  • “A new player at the flagellar motor: FliL controls both motor output and bias” at BLAST XIII, (Tucson, USA; January 2015)                         *Recipient of the Robert M. Macnab award.
  • “c-di-GMP sensing at the flagella motor” at the Gordon Research Conference on Sensory Transduction in Microorganisms (Ventura Beach, LA, USA, January, 2014)
  • “FliL interacts both physically and functionally with the flagellar stator proteins MotAB in Salmonella” at the Gordon Research Conference on Sensory Transduction in Microorganisms (Ventura Beach, USA, Jan. 2012)
  • coli transcriptome dynamics during the transition from anaerobic to aerobic growth” and contributed to an oral presentation “Transcriptional profiling of bacterial responses to nitrosative, oxidative and metal stresses in a chemostat” Society for General Microbiology Meeting (York, UK, September, 2006)
  • “Characterization of the coli ydhY-T operon: regulation by FNR and NarL/P transcription factors” at the European Federation of Biotechnology meeting on Microbial Respiratory Chains (Tomar, Portugal; March 2006)
  • “Investigating the FNR-Modulon. A Post-Genomic Approach” at the Annual University of Sheffield Biological Sciences Symposium (Sheffield, UK; April, 2004) * Recipient of the Sir Hans Krebs Award
  • “DNA target sequence and FNR-dependent gene expression” at the European Federation of Biotechnology meeting, Physiology, Biochemistry and Genetic Regulation of Electron Transfer in Bacteria (Walberberg, Germany; October 2003)

 

BIO 311C - Introductory Biology I

 

Serves as a general introduction to biology at the molecular level. Broadly, in terms of macromolecules, cell structure and function, energy transformation and flow (including respiration and photosynthesis), and how genetic information is expressed, and passed from one generation to another.

 

BIO 311D - Introductory Biology II

 

Serves as a general introduction to biology, covering diverse topics such as reproduction, inheritance, evolution, phylogeny, biodiversity, ecology, and experimental design.