Contact

Department of MBS

Phone: (512) 471-5105
Fax: (512) 471-1218
 

NHB 2.606, Stop A5000
100 East 24th St.
Austin TX 78712

TUCKER, Haley O

Haley Tucker

Professor
Molecular Biosciences

Marie Betzner Morrow Centennial Chair

haleytucker@austin.utexas.edu

Phone: 512-475-7705

Office Location
NMS 2.306

Postal Address
The University of Texas at Austin
Molecular Biosciences, College of Natural Sciences
2506 Speedway
Austin, TX 78712

Research Summary:

We study trancriptional control of fate and differention of stem cells, including those that make blood and those that make placentas.  Our interests also include reprogramming somatic cells to stem cells and developing new methodology for producing vaccines.  We employ a number of genomic, biochemical and genetic approaches. By understanding normal development we hope to learn what goes wrong to promote hematopoietic malignancy and birth defects.

Publications:

Wang H, Geng J, Wen X, Bi E, Kossenkov AV, Wolf AI, Tas J, Choi YS, Takata H, Day TJ, Chang LY, Sprout SL, Becker EK, Willen J, Tian L, Wang X, Xiao C, Jiang P, Crotty S, Victora GD, Showe LC, Erikson J, Tucker HO, Hu H. (2014). The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells. Nat Immunol. 2014 May 25. doi: 10.1038/ni.2890. [Epub ahead of print] PMID: 24859450.
 
Popowski M, Lee BK, Templeton T, Liu H, Miner C, Rhee C, Kim J, Iyer VR, Orlanki S, Bergman Y, Webb CF and Tucker H. (2014). The Bright/Arid3a transcription factor provides a singular barrier to somatic cell reprogramming though direct repression of Oct4, Sox2 and Nanog. Cell Stem Cell Reports. 2(1):26-35.
 
Ippolito GC; Dekker JD; Wang Y-S; Shaffer AL; Lin J; Wall JK; Lee B-S; Staudt LM; Liu P; Liu Y-J; Tucker H. (2014). Dendritic cell fate is determined by the BCL11A transcription factor. Proc.Natl. Acad. Sci. ;111(11):998-1006.

Leishman E, Howard JM, Garcia CE, Miao Q, Ku A, Dekker JD, Tucker H. (2013). Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18. Development: 140(18):3809-18.