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Ilya J Finkelstein
Associate Professor
Molecular Biosciences
Lorene Morrow Kelley Endowed Faculty Fellowship FundBiophysical Studies of Molecular Machinesifinkelstein@cm.utexas.edu
Phone: 512-471-1394
Office Location
MBB 3.422
Postal Address
2500 SPEEDWAY
AUSTIN, TX 78712-
- B.S., in Chemistry - UC Berkeley (2001)
- Ph.D., in Chemistry - Stanford University (2007)
- Postdoctoral Training in Molecular Biophysics - Columbia University Medical Center (2012)
Research Interests
We develop biophysical tools to understand how molecular machines edit and repair our genomes. Current focus areas include the biology and applications of CRISPR adaptive immunity, mammalian gene editing, and the mechanisms of genome maintenance. Our interdisciplinary research program combines single-molecule biophysics, hihgh-throughput assays and micro-/nano-scale engineering to understand how organisms are able to maintain and edit their genomic integrity.
Prospective students and postdocs are encouraged to reach out via e-mail.
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Latest publications
Finkelstein lab website (with PDFs)
2021
William N. Voss, Yixuan J. Hou, Nicole V. Johnson, George Delidakis, Jin Eyun Kim, Kamyab Javanmardi, Andrew P. Horton, Foteini Bartzoka, Chelsea J. Paresi, Yuri Tanno, Chia-Wei Chou, Shawn A. Abbasi, Whitney Pickens, Katia George, Daniel R. Boutz, Dalton M. Towers, Jonathan R. McDaniel, Dnaiel Billick, Jule Goike, Lori Rowe, Dhwani Batra, Jan Pohl, Justin Lee, Shivaprakash Gangappa, Suryaprakash Sambhara, Michelle Gadush, Nianshuang Wang, Maria D. Person, Brent L. Iverson, Jimmy D. Gollihar, John Dye, Andrew Herbert, Ilya J. Finkelstein, Ralph S. Baric, Jason S. McLellan, George Georgiou, Jason L. Lavinder†, Gregory C. Ippolito† († co-corresponding)
Science. DOI: 10.1126/science.abg5268 PMID: 33947773Carlos Calcines-Cruz, Ilya J. Finkelstein† & Armando Hernandez-Garcia† († co-corresponding)
Nano Letters. DOI: 10.1021/acs.nanolett.0c04640 PMID: 33729813S. Wesley Long, Randall J. Olsen, Paul A. Christensen, Sishir Subedi, Robert Olson, James J. Davis, Matthew Ojeda Saavedra, Prasanti Yerramilli, Layne Pruitt, Kristina Reppond, Madison N. Shyer, Jessica Cambric, Ilya J. Finkelstein, Jimmy Gollihar, James M. Musser(* co-first authors) († co-corresponding)
American Journal of Pathology. DOI: 10.1016/j.ajpath.2021.03.004 PMID: 33741335Isabel Strohkendl, Fatema A. Saifuddin, Bryan A. Gibson, Michael K. Rosen, Rick Russell† & Ilya J. Finkelstein† († co-corresponding)
Science Advances. 7 (11): eabd6030 DOI: 10.1126/sciadv.abd6030 PMID: 336921022020
Scott Wesley Long*, Randall J. Olsen*, Paul A. Christensen*, David W. Bernard, James J. Davis, Maulik Shukla, Marcus Nguyen, Matthew Ojeda Saavedra, Prasanti Yerramilli, Layne Pruitt, Sishir Subedi, Hung-Che Kuo, Heather Hendrickson, Ghazaleh Eskandari, Hoang A.T. Nguyen, J. Hunter Long, Muthiah Kumaraswami, Jule Goike, Daniel Boutz, Jimmy Gollihar, Jason S. McLellan, Chia-Wei Chou, Kamyab Javanmardi, Ilya J. Finkelstein & James Musser (* co-first authors)
mBio. 11 (6): e02707-20 DOI: 10.1128/mBio.02707-20 PMID: 33127862Stephen K. Jones Jr.*, John A. Hawkins*, Nicole V. Johnson, Cheulhee Jung, Kuang Hu, James R. Rybarski, Janice S. Chen, Jennifer A. Doudna, William H. Press & Ilya J. Finkelstein; (* co-first authors)
Nature Biotechnology. DOI: 10.1038/s41587-020-0646-5 PMID: 32895548Corey Frazer*, Mae I. Staples*, Yoori Kim, Matthew Hirakawa, Maureen A. Dowell, Nicole V. Johnson, Aaron D. Hernday, Veronica H. Ryan, Nicolas L. Fawzi, Ilya J. Finkelstein & Richard J. Bennett (* co-first authors)
Nature Microbiology. DOI: 10.1038/s41564-020-0760-7 PMID: 32719507Ching-Lin Hsieh, Jory A. Goldsmith, Jeffrey M. Schaub, Andrea M. DiVenere, Hung-Che Kuo, Kamyab Javanmardi, Kevin C. Le, Daniel Wrapp, Alison Gene-Wei Lee, Yutong Liu, Chia-Wei Chou, Patrick O. Byrne, Christy K. Hjorth, Nicole V. Johnson, John Ludes-Meyers, Annalee W. Nguyen, Juyeon Park, Nianshuang Wang, Dzifa Amengor, Jason J. Lavinder, Gregory C. Ippolito, Jennifer A. Maynard†, Ilya J. Finkelstein† & Jason S. McLellan† († co-corresponding)
Science. DOI: 10.1126/science.abd0826 PMID: 32703906William H. Press, John A. Hawkins, Stephen K. Jones Jr., Jeffrey M. Schaub, Ilya J. Finkelstein
Proc Natl Acad Sci USA. DOI: 10.1073/pnas.2004821117 PMID: 32675237Hongshan Zhang, Jeffrey M. Schaub & Ilya J. Finkelstein
Nucleic Acids Research. DOI: 10.1093/nar/gkaa559 PMID: 32621611Rajashree Deshpande, Logan Myler, Michael Soniat, Nodar Makharashvili, Linda Lee, Susan Lees-Miller, Ilya Finkelstein & Tanya Paull
Science Advances. 6 (2): eaay0922 DOI: 10.1126/sciadv.aay0922 PMID: 31934630Yoori Kim*, Zhubing Shi*, Hongshan Zhang, Ilya J. Finkelstein† & Hongtao Yu† (* co-first authors) († co-corresponding)
Science. DOI: 10.1126/science.aaz4475 PMID: 31780627Anna L Mallam*, Wisath Sae-Lee, Jeffrey M Schaub, Fan Tu, Anna Battenhouse, Yu Jin Jang, Jonghwan Kim, John B. Wallingford, Ilya J Finkelstein, Edward M Marcotte† & Kevin Drew*† (* co-first authors) († co-corresponding)
Cell Reports. 29 (5): 1351-1368 DOI: 10.1016/j.celrep.2019.09.060 PMID: 31665645Anna J. Simon, Andrew D. Ellington & Ilya J. Finkelstein
Nucleic Acids Research. 47 (21): 11007-11019 DOI: 10.1093/nar/gkz865 PMID: 31598685Kevin J Forsberg, Ishan V Bhatt, Danica T. Schmidtke, Kamyab Javanmardi, Kaylee E Dillard, Barry L Stoddard, Ilya J Finkelstein, Brett K Kaiser & Harmit S Malik
eLife. DOI: 10.7554/eLife.46540 PMID: 31502535Michael M. Soniat, Logan R. Myler, Hung-Che Kuo, Tanya T. Paull & Ilya J. Finkelstein
Molecular Cell. 75 (1): 145-153 DOI: 10.1016/j.molcel.2019.05.005 PMID: 31153714Marie-Christine Caron*, Ajit K. Sharma*, Julia O’Sullivan, Logan R. Myler, Maria Tedim Ferreira, Amélie Rodrigue, Yan Coulombe, Chantal Ethier, Jean-Philippe Gagné, Marie-France Langelier, John M. Pascal, Ilya J. Finkelstein, Michael J. Hendzel†, Guy G. Poirier† & Jean-Yves Masson† (* co-first authors) († co-corresponding)
Nature Communications. 10 (1): 2954 DOI: 10.1038/s41467-019-10741-9 PMID: 31273204Logan R. Myler, Michael M. Soniat, Xiaoming Zhang, Rajashree A. Deshpande, Tanya T. Paull & Ilya J. Finkelstein
Methods Mol Biol. DOI: 10.1007/978-1-4939-9520-2_20 PMID: 31147924Michael M. Soniat, Logan R. Myler & Ilya J. Finkelstein
Methods Mol Biol. DOI: 10.1007/978-1-4939-9500-4_14 PMID: 31127580Kaylee E. Dillard, Jeffrey M. Schaub, Maxwell W. Brown, Fatema A. Saifuddin, Yibei Xiao, Erik Hernandez, Samuel D. Dahlhauser, Eric v. Anslyn, Ailong Ke, Ilya J. Finkelstein
Methods in Enzymology. DOI: 10.1016/bs.mie.2018.10.031 PMID: 306916542018-
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Awards
2021 Norman Hackerman Award in Chemical Sciences, Welch Foundation
2018 Fellow, William H. Tonn Professorial Fund
2015 National Science Foundation CAREER Award
2014 American Federation of Aging Research Junior Fellow
2013 Emerging Investigator, Molecular BioSystems
2013 Protege, The Academy of Medicine, Engineering and Science of Texas
2012 CPRIT Fellow in Cancer Research
2011 Pathway to Independence Award (NIH K99/R00)
2007 NRSA Postdoctoral Fellow (NIH F32)
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BCH339M: Structure and Function of Molecular Machines
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An updated list of current Finkelstein lab website is available on the Finkelstein lab website.
Interested in joining the team?
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The Finkelstein group is an interdisciplinary team of biophysicists seeking to discover how molecular machines maintain and edit our genetic information. We combine molecular biology with high-throughput approaches and single-molecule biophysics. We are especially interested in scientists that are at the interface of biophysics, bioinformatics, and molecular biology. For specific job openings, see below:
Postdoc Openings
Applicants with a strong background in bioinformatics, molecular (bio)physics, biomedical engineering, or computer science are strongly encouraged to apply. However, enthusiasm and a strong work ethic in your graduate career are the only requirements. Please email Ilya a CV and a cover letter that explains why you are interested in the lab.
Graduate Students
Prospective graduate students that are interested in molecular biophysics, bioinformatics, or biomedical engineering can join the lab by applying to a number of graduate programs at UT Austin. Possibilities include:
Undergraduate Students
The laboratory strives to include exceptional undergraduates with prior research experience in the life of the lab. To get started in research, please apply to these or related Freshman Research Initiative streams:
Students that are interested in joining the lab are encouraged to e-mail Ilya a short (one-page) summary of their prior research project. Unfortunately, I cannot consider applications without a one-page research summary.
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