Contact

Department of MBS

Phone: (512) 471-5105
Fax: (512) 471-1218
 

NHB 2.606, Stop A5000
100 East 24th St.
Austin TX 78712

Stovall, Gwen

Gwendolyn M Stovall

Clinical Assistant Professor
College of Natural Sciences


Gwen Stovall supervises the FRI Aptamer Stream, where students use biochemistry and molecular biology to develop tools made of RNA and DNA.

gwenstovall@utexas.edu

Phone: 512-232-8348

Office Location
PAI 3.04N

Postal Address
The University of Texas at Austin
College of Natural Sciences
1 University Station G2500
Austin, TX 78712

Ph.D., The University of Texas at Austin (2011)

B.S.Chem., The University of Georgia (1999)

B.S. in Biochemistry and Molecular Biology, The University of Georgia (1999)

Research Interests

A part of the University of Texas Freshman Research Initiative, the Aptamer Stream uses oligonucleotide chemistry, in vitro selection methodology, and biochemistry to develop novel therapeutics, diagnostics, and molecular sensors.  Based on the technology developed by Andrew D. Ellington, our tool of choice for the development of these applications is an "aptamer," an oligonucleotide binding species.  We use the methods of in vitro selection methodology to identify aptamers against a variety of targets.

A part of the University of Texas Freshman Research Initiative, the Aptamer Stream uses oligonucleotide chemistry, in vitro selection methodology, and biochemistry to develop novel therapeutics, diagnostics, and molecular sensors.  Based on the technology developed by Andrew D. Ellington, our tool of choice for the development of these applications is an "aptamer," an oligonucleotide binding species.  We use the methods of in vitro selection methodology to identify aptamers against a variety of targets.

  1. Stovall, GM, Bedenbaugh, R, Singh, S, Meyer, AJ, Hatala, PJ, Ellington, AD, Hall, B:  In Vitro Selection Using Modified or Unnatural Nucleotides.  Current Protocols in Nucleic Acid Chemistry 2014, 9.6.1–9.6.33.
  2. Ledbetter, MP, Hwang, TW, Stovall, GM, Ellington AD: Continuous in vitro Evolution of a Ribozyme Ligase: A Model Experiment for The Evolution of a Biomolecule.  Biochemistry and Molecular Biology Education 2013, 41(6):433-42.  doi: 10.1002/bmb.20742.
  3. Stovall GM:  Evaluation of Protein Aggregation and Organismal Fitness.  PhD Dissertation, University of Texas at Austin, May 2011.  
  4. Narayanaswamy R, Levy M, Tsechansky M, Stovall GM, O’Connell J, Mirrielees J, Ellington AD, Marcotte EM:  Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation.  Proc Natl Acad Sci USA 2009, 106(25):10147-52.  
  5. Li N, Ebright JN, Stovall GM, Chen X, Nguyen H, Signh A, Syrett A, Ellington AD:  Technical and Biological Issues Relevant to Cell Typing by Aptamers.  Journal of Proteome Research 2009, 8(5):2438-48. 
  6. Lee JF, Stovall GM, Ellington AD: Aptamer therapeutics advance. Curr Opin Chem Biol 2006, 10:282-289.
  7. Stovall GM, Cox JC, Ellington AD: Automated optimization of aptamer selection buffer conditions. Journal of the Association for Laboratory Automation 2004, 9:117-22.

The University of Texas College of Natural Sciences Teaching Excellance Award in Molecular Biosciences (2014).